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Company

D.Nature
Website

http://www.d-nature.co.kr
Business Sector

MedicineㆍBio
Key products and services

ANACELL - "JAK inhibition and Wnt regulation" cosmetic approved for alopecia prevention
Brochure

2022_ANACELL_DNature_En.pdf [View] [Download]
Corporate Video

https://youtu.be/Zc8cNgOQ7v0

Company Profile

D.Nature developed a unique technology in the field of JAK inhibitors, which only 6 global pharmaceutical companies have approved drugs, and obtained the approval of the functional cosmetic for alopecia prevention as a non-designated substance product after reviewing clinical trials by the Ministry of Food and Drug Safety in March. 
In June, the FDA approved Lilly's JAK inhibitor "Olumient" for the treatment of severe alopecia areata. 
In a market estimated to be worth more than 65 Bn USD per year, we first secured a clue about the future androgenetic alopecia treatment. 
With the previous approval, we are implementing a differentiated strategy that combines commercial performance with new drug development.

Brochure Introduction Video

ANACELL, Functional cosmetics approved for alopecia prevention with proven pharmacological mechanism of "Wnt control" that converts hair follicles into growth phase

"Alopecia" can be seen as a condition in which a number of hair follicles cannot convert to the growth phase due to various reasons (immune, hormone, aging, etc.).
In the middle of 2000, it was revealed that Wnt signaling must be activated for hair follicle transition to growth phase, and in 2015, it was announced that growth phase transition was possible through a commercially available JAK inhibitor.
However, this technology is owned by global Big Pharma's, and it is not popularized due to patents and drug price (monthly cost of 5,000 USD).
Though FDA approved Lilly's 'Olumient' for severe alopecia areata treatment, price of the drug is still burden for patients(in EU 1,300 euro/month)

We developed CMX, a unique natural material, and confirmed hair growth through human application tests, and the results were published in international journals.
In last March, we obtained the functional cosmetic for alopecia prevention from the Ministry of Food and Drug Safety through reviewing the clinical trial results for 18 months. It was the first case of non-designated new substance product, and very strict.

"Anacell", a functional cosmetic whose Wnt activity has been verified for the first time in the world, provides a new option to patients with alopecia at a reasonable cost.

-Proven mechanism of Wnt/beta catenin regulation for hair regeneration (anagen initiation)
- Containing Brevilin A over 200mg/package (standard material price is over 8,000 USD)
- Completing human application test of alopecia prevention(by the guidelines of the Korean Ministry of Food and Drug Safety)
- Approved Functional Cosmetic for Anti-Hair Loss
(Korean Ministry of Food and Drug Safety)

- Easy-to-use 1 ml ampules with the applicator(30 ampules/box)

People using Anacell can find out following efficacy;
1. In 2 weeks, they can see the amount of hair loss decrease.(Wnt pathway working)
2. They can feel their hair stronger and thicker than before.(hair volume changing)
3. They can see or feel new hairs after 8 ~ 12 weeks(at least after 4 weeks)
*minimum 2 times/week recommended.

https://www.kmall24.com/products/97004057
https://youtu.be/Zc8cNgOQ7v0

Type of investment
Desired investment amount

USD 1 ~ 5 million (Share: 30 %)
Considerations
Funding History

Yes
Start-up

Series A
Pitch Deck

20221005_ANACELL_PoC_LoReal.pdf
Pitch Video(YouTube)

https://youtu.be/Vtj-_7tSWHo

Invest KOREA

KOTRA site